February 25, 2026
Speakers: Stefania Cinquino, Florian Timo Ludwig, and Lisa Berman-Booty
Educational Level: Foundational, Practical

Intrathecal (IT) and intracerebroventricular (ICV) administration enable direct access to the central nervous system but introduce route-specific complexities in nonclinical study design, execution, and interpretation. This webinar translates those complexities into practical principles for toxicologists aiming to deliver sound risk assessment and regulatory-ready packages. The speakers will examine how administration parameters, surgical technique, catheter/device considerations, dosing paradigms, and species selection (rodent vs. nonrodent) shape data quality and translational relevance. Direct IT delivery can produce procedure-related microscopic findings from localized injury or irritation of CNS tissues; however, microscopic changes of similar character and/or severity may also arise from the test article (TA), complicating interpretation. Approaches that can be used to help differentiate procedure-related from TA-related microscopic changes will also be discussed.

- Technical Considerations for Intrathecal and Intracerebroventricular Routes: Essential Insights for Toxicologists, Stefania Cinquino, BSc
- Intrathecal Administration in Non-Human Primates: Technique, Study Designs, Challenges, Florian Timo Ludwig, PhD
- Procedure-Related Microscopic Findings Secondary to Intrathecal Dosing of Test-Articles, Lisa Berman-Booty, VMD, PhD, DACVP