Ototoxicity refers to the potential for certain chemicals or drugs to cause damage to the inner ear and result in hearing loss or balance problems. This type of ototoxicity can occur even in the absence of any clinical symptoms or signs of hearing loss.

Currently, there is ongoing research in this area to better understand the mechanisms by which ototoxicity occurs and to identify potential ways to prevent or mitigate its effects. Some of the key areas of focus include developing more sensitive and reliable methods for detecting ototoxicity, identifying and testing new drugs or compounds that may be less toxic to the inner ear, and exploring the use of protective agents or therapies to prevent or reduce the risk of ototoxicity.

We will discuss the nonclinical aspects and needs for these study types and how they are conducted. Overall, the goal of this research is to improve our understanding of nonclinical ototoxicity and to develop new strategies for minimizing its potential impact on individuals who may be at risk.